1f8z
From Proteopedia
(New page: 200px<br /> <applet load="1f8z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f8z" /> '''NMR STRUCTURE OF THE SIXTH LIGAND-BINDING M...) |
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'''NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR'''<br /> | '''NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The sixth ligand-binding module of the low-density lipoprotein receptor | + | The sixth ligand-binding module of the low-density lipoprotein receptor contributes to the binding of apolipoprotein B100-containing lipoproteins. 1H NMR spectroscopy, DYANA and X-PLOR structure calculations were used to determine that this module has a well defined structure with a backbone conformation similar to other modules. Structures from calculations that simulated the presence of a calcium ion showed increased resolution without large increases in energy, increased deviations from idealised geometry or violations of experimental constraints. Investigation of the surface properties of this module indicates there are significant differences from the fifth module, which binds apolipoprotein E-containing lipoproteins in addition to apolipoprotein B100-containing lipoproteins. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1F8Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1F8Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8Z OCA]. |
==Reference== | ==Reference== | ||
Three-dimensional NMR structure of the sixth ligand-binding module of the human LDL receptor: comparison of two adjacent modules with different ligand binding specificities., Clayton D, Brereton IM, Kroon PA, Smith R, FEBS Lett. 2000 Aug 18;479(3):118-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10981718 10981718] | Three-dimensional NMR structure of the sixth ligand-binding module of the human LDL receptor: comparison of two adjacent modules with different ligand binding specificities., Clayton D, Brereton IM, Kroon PA, Smith R, FEBS Lett. 2000 Aug 18;479(3):118-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10981718 10981718] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Brereton, I | + | [[Category: Brereton, I M.]] |
| - | [[Category: Clayton, D | + | [[Category: Clayton, D J.]] |
| - | [[Category: Kroon, P | + | [[Category: Kroon, P A.]] |
[[Category: Smith, R.]] | [[Category: Smith, R.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: ligand-binding domain]] | [[Category: ligand-binding domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:36:06 2008'' |
Revision as of 10:36, 21 February 2008
|
NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR
Contents |
Overview
The sixth ligand-binding module of the low-density lipoprotein receptor contributes to the binding of apolipoprotein B100-containing lipoproteins. 1H NMR spectroscopy, DYANA and X-PLOR structure calculations were used to determine that this module has a well defined structure with a backbone conformation similar to other modules. Structures from calculations that simulated the presence of a calcium ion showed increased resolution without large increases in energy, increased deviations from idealised geometry or violations of experimental constraints. Investigation of the surface properties of this module indicates there are significant differences from the fifth module, which binds apolipoprotein E-containing lipoproteins in addition to apolipoprotein B100-containing lipoproteins.
Disease
Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]
About this Structure
1F8Z is a Single protein structure of sequence from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Three-dimensional NMR structure of the sixth ligand-binding module of the human LDL receptor: comparison of two adjacent modules with different ligand binding specificities., Clayton D, Brereton IM, Kroon PA, Smith R, FEBS Lett. 2000 Aug 18;479(3):118-22. PMID:10981718
Page seeded by OCA on Thu Feb 21 12:36:06 2008
