1fav
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The three-dimensional structure of the complex between an HIV-1 cell-entry | + | The three-dimensional structure of the complex between an HIV-1 cell-entry inhibitor selected from screening a combinatorial library of non-natural building blocks and the central, trimeric, coiled-coil core of HIV-1 gp41 has been determined by X-ray crystallography. The biased combinatorial library was designed to identify ligands binding in nonpolar pockets on the surface of the coiled-coil core of gp41. The crystal structure shows that the non-peptide moiety of the inhibitor binds to the targeted cavity in two different binding modes. This result suggests a strategy for increasing inhibitor potency by use of a second-generation combinatorial library designed to give simultaneous occupancy of both binding sites. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Chopra, R.]] | [[Category: Chopra, R.]] | ||
[[Category: Ferrer, M.]] | [[Category: Ferrer, M.]] | ||
| - | [[Category: Harrison, S | + | [[Category: Harrison, S C.]] |
[[Category: Oprian, D.]] | [[Category: Oprian, D.]] | ||
| - | [[Category: Schreiber, S | + | [[Category: Schreiber, S L.]] |
| - | [[Category: Skehel, J | + | [[Category: Skehel, J J.]] |
[[Category: Strassmaier, T.]] | [[Category: Strassmaier, T.]] | ||
[[Category: Weissenhorn, W.]] | [[Category: Weissenhorn, W.]] | ||
| - | [[Category: Wiley, D | + | [[Category: Wiley, D C.]] |
[[Category: Zhou, G.]] | [[Category: Zhou, G.]] | ||
[[Category: gp41]] | [[Category: gp41]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:36:45 2008'' |
Revision as of 10:36, 21 February 2008
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THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE
Overview
The three-dimensional structure of the complex between an HIV-1 cell-entry inhibitor selected from screening a combinatorial library of non-natural building blocks and the central, trimeric, coiled-coil core of HIV-1 gp41 has been determined by X-ray crystallography. The biased combinatorial library was designed to identify ligands binding in nonpolar pockets on the surface of the coiled-coil core of gp41. The crystal structure shows that the non-peptide moiety of the inhibitor binds to the targeted cavity in two different binding modes. This result suggests a strategy for increasing inhibitor potency by use of a second-generation combinatorial library designed to give simultaneous occupancy of both binding sites.
About this Structure
1FAV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core., Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC, Bioorg Med Chem. 2000 Sep;8(9):2219-27. PMID:11026535
Page seeded by OCA on Thu Feb 21 12:36:45 2008
