1zhm
From Proteopedia
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===Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Benzamidine (S434A-T475A-K437 Mutant)=== | ===Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Benzamidine (S434A-T475A-K437 Mutant)=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]], Factor XI deficiency, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1zhm]] is a 1 chain structure of [[Factor XIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHM OCA]. | |
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| + | ==See Also== | ||
| + | *[[Factor XIa|Factor XIa]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016204896</ref><ref group="xtra">PMID:016085935</ref><ref group="xtra">PMID:019178150</ref><references group="xtra"/> |
[[Category: Coagulation factor XIa]] | [[Category: Coagulation factor XIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Weaver, D T.]] | [[Category: Weaver, D T.]] | ||
[[Category: Benzamidine]] | [[Category: Benzamidine]] | ||
| + | [[Category: Blood clotting]] | ||
[[Category: Factor xi]] | [[Category: Factor xi]] | ||
| - | + | [[Category: Hydrolase]] | |
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Revision as of 22:17, 26 July 2012
Contents |
Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Benzamidine (S434A-T475A-K437 Mutant)
Template:ABSTRACT PUBMED 16204896
About this Structure
1zhm is a 1 chain structure of Factor XIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Jin L, Pandey P, Babine RE, Weaver DT, Abdel-Meguid SS, Strickler JE. Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1418-25. Epub 2005, Sep 28. PMID:16204896 doi:http://dx.doi.org/10.1107/S0907444905024340
- Navaneetham D, Jin L, Pandey P, Strickler JE, Babine RE, Abdel-Meguid SS, Walsh PN. Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2. J Biol Chem. 2005 Oct 28;280(43):36165-75. Epub 2005 Aug 6. PMID:16085935 doi:10.1074/jbc.M504990200
- Yang L, Sun MF, Gailani D, Rezaie AR. Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor. Biochemistry. 2009 Feb 24;48(7):1517-24. PMID:19178150 doi:10.1021/bi802298r
