1o9f
From Proteopedia
(New page: 200px<br /> <applet load="1o9f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o9f, resolution 2.7Å" /> '''STRUCTURAL VIEW OF A...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1O9F is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]] with FSC as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O9F OCA]]. | + | 1O9F is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]] with FSC as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O9F OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: plant plasma membrane (h+)atpase]] | [[Category: plant plasma membrane (h+)atpase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:01:52 2007'' |
Revision as of 11:57, 30 October 2007
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STRUCTURAL VIEW OF A FUNGAL TOXIN ACTING ON A 14-3-3 REGULATORY COMPLEX
Overview
The fungal phytotoxin fusicoccin stabilizes the interaction between the, C-terminus of the plant plasma membrane H(+)-ATPase and 14-3-3 proteins, thus leading to permanent activation of the proton pump. This results in, an irreversible opening of the stomatal pore, followed by wilting of, plants. Here, we report the crystal structure of the ternary complex, between a plant 14-3-3 protein, fusicoccin and a phosphopeptide derived, from the C-terminus of the H(+)-ATPase. Comparison with the corresponding, binary 14-3-3 complexes indicates no major conformational change induced, by fusicoccin. The compound rather fills a cavity in the, protein-phosphopeptide interaction surface. Isothermal titration, calorimetry indicates that the toxin alone binds only weakly to 14-3-3 and, that peptide and ... [(full description)]
About this Structure
1O9F is a [Protein complex] structure of sequences from [Nicotiana tabacum] with FSC as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex., Wurtele M, Jelich-Ottmann C, Wittinghofer A, Oecking C, EMBO J. 2003 Mar 3;22(5):987-94. PMID:12606564
Page seeded by OCA on Tue Oct 30 14:01:52 2007
