1o9u

From Proteopedia

Revision as of 11:57, 30 October 2007

GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE

Overview

Glycogen synthase kinase 3beta (GSK3beta) is a serine/threonine kinase, involved in insulin, growth factor and Wnt signalling. In Wnt signalling, GSK3beta is recruited to a multiprotein complex via interaction with axin, where it hyperphosphorylates beta-catenin, marking it for ubiquitylation, and destruction. We have now determined the crystal structure of GSK3beta, in complex with a minimal GSK3beta-binding segment of axin, at 2.4 A, resolution. The structure confirms the co-localization of the binding, sites for axin and FRAT in the C-terminal domain of GSK3beta, but reveals, significant differences in the interactions made by axin and FRAT, mediated by conformational plasticity of the 285-299 loop in GSK3beta., Detailed comparison of the axin and FRAT GSK3beta complexes allows the, ... [(full description)]

About this Structure

1O9U is a [Protein complex] structure of sequences from [Homo sapiens] with ADZ as [ligand]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex., Dajani R, Fraser E, Roe SM, Yeo M, Good VM, Thompson V, Dale TC, Pearl LH, EMBO J. 2003 Feb 3;22(3):494-501. PMID:12554650

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