1o94
From Proteopedia
(New page: 200px<br /> <applet load="1o94" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o94, resolution 2.00Å" /> '''TERNARY COMPLEX BET...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1O94 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]] with FMN, ADP, SF4 and AMP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.99.7 1.5.99.7]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O94 OCA]]. | + | 1O94 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]] with FMN, ADP, SF4 and AMP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_1.5.8.2 Transferred entry: 1.5.8.2]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.99.7 1.5.99.7]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O94 OCA]]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Methylophilus methylotrophus]] | [[Category: Methylophilus methylotrophus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Transferred entry: 1.5.8.2]] | ||
[[Category: Basran, J.]] | [[Category: Basran, J.]] | ||
[[Category: Leys, D.]] | [[Category: Leys, D.]] | ||
| Line 27: | Line 28: | ||
[[Category: protein complex]] | [[Category: protein complex]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:02:03 2007'' |
Revision as of 11:57, 30 October 2007
|
TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN
Overview
Here we report the crystal structures of a ternary electron transfer, complex showing extensive motion at the protein interface. This, physiological complex comprises the iron-sulfur flavoprotein, trimethylamine dehydrogenase and electron transferring flavoprotein (ETF), from Methylophilus methylotrophus. In addition, we report the crystal, structure of free ETF. In the complex, electron density for the FAD domain, of ETF is absent, indicating high mobility. Positions for the FAD domain, are revealed by molecular dynamics simulation, consistent with crystal, structures and kinetic data. A dual interaction of ETF with trimethylamine, dehydrogenase provides for dynamical motion at the protein interface: one, site acts as an anchor, thereby allowing the other site to sample a large, range of ... [(full description)]
About this Structure
1O94 is a [Protein complex] structure of sequences from [Methylophilus methylotrophus] with FMN, ADP, SF4 and AMP as [ligands]. Active as [Transferred entry: 1.5.8.2], with EC number [1.5.99.7]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Extensive conformational sampling in a ternary electron transfer complex., Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS, Nat Struct Biol. 2003 Mar;10(3):219-25. PMID:12567183
Page seeded by OCA on Tue Oct 30 14:02:03 2007
