1gi8
From Proteopedia
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{{STRUCTURE_1gi8| PDB=1gi8 | SCENE= }} | {{STRUCTURE_1gi8| PDB=1gi8 | SCENE= }} | ||
===A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE=== | ===A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[1gi8]] is a 2 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GI8 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Urokinase|Urokinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:011292354</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: U-plasminogen activator]] | [[Category: U-plasminogen activator]] | ||
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[[Category: Verner, E.]] | [[Category: Verner, E.]] | ||
[[Category: Young, W.]] | [[Category: Young, W.]] | ||
| + | [[Category: Blood clotting]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Oxyanion hole water]] | [[Category: Oxyanion hole water]] | ||
[[Category: Shift of pka of his57]] | [[Category: Shift of pka of his57]] | ||
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[[Category: Very short hydrogen bond]] | [[Category: Very short hydrogen bond]] | ||
[[Category: Zn+2-mediated inhibition]] | [[Category: Zn+2-mediated inhibition]] | ||
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Revision as of 22:51, 26 July 2012
Contents |
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Template:ABSTRACT PUBMED 11292354
About this Structure
1gi8 is a 2 chain structure of Urokinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J Mol Biol. 2001 Apr 13;307(5):1451-86. PMID:11292354 doi:http://dx.doi.org/10.1006/jmbi.2001.4516
Categories: Homo sapiens | U-plasminogen activator | Elrod, K. | Hatayte, J. | Janc, J. | Katz, B A. | Link, J. | Litvak, J. | Luong, C. | Mackman, R L. | Rai, R. | Rice, K. | Rice, M. | Sideris, S. | Spencer, J. | Sprengeler, P A. | Verner, E. | Young, W. | Blood clotting | Hydrolase | Oxyanion hole water | Shift of pka of his57 | Specificity | Structure-based drug design | Three-centered | Thrombin | Trypsin | Urokinase | Very short hydrogen bond | Zn+2-mediated inhibition
