1hdh
From Proteopedia
(New page: 200px<br /> <applet load="1hdh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hdh, resolution 1.3Å" /> '''ARYLSULFATASE FROM P...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HDH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with CA and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.1 3.1.6.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HDH OCA]]. | + | 1HDH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with CA and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Arylsulfatase Arylsulfatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.1 3.1.6.1]]. Structure known Active Site: CA1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HDH OCA]]. |
==Reference== | ==Reference== | ||
1.3 A structure of arylsulfatase from Pseudomonas aeruginosa establishes the catalytic mechanism of sulfate ester cleavage in the sulfatase family., Boltes I, Czapinska H, Kahnert A, von Bulow R, Dierks T, Schmidt B, von Figura K, Kertesz MA, Uson I, Structure. 2001 Jun;9(6):483-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11435113 11435113] | 1.3 A structure of arylsulfatase from Pseudomonas aeruginosa establishes the catalytic mechanism of sulfate ester cleavage in the sulfatase family., Boltes I, Czapinska H, Kahnert A, von Bulow R, Dierks T, Schmidt B, von Figura K, Kertesz MA, Uson I, Structure. 2001 Jun;9(6):483-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11435113 11435113] | ||
| + | [[Category: Arylsulfatase]] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: sulfatase]] | [[Category: sulfatase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:02:46 2007'' |
Revision as of 11:58, 30 October 2007
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ARYLSULFATASE FROM PSEUDOMONAS AERUGINOSA
Overview
BACKGROUND: Sulfatases constitute a family of enzymes with a highly, conserved active site region including a Calpha-formylglycine that is, posttranslationally generated by the oxidation of a conserved cysteine or, serine residue. The crystal structures of two human arylsulfatases, ASA, and ASB, along with ASA mutants and their complexes led to different, proposals for the catalytic mechanism in the hydrolysis of sulfate esters., RESULTS: The crystal structure of a bacterial sulfatase from Pseudomonas, aeruginosa (PAS) has been determined at 1.3 A. Fold and active site region, are strikingly similar to those of the known human sulfatases. The, structure allows a precise determination of the active site region, unequivocally showing the presence of a Calpha-formylglycine hydrate as, the ... [(full description)]
About this Structure
1HDH is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with CA and SO4 as [ligands]. Active as [Arylsulfatase], with EC number [3.1.6.1]. Structure known Active Site: CA1. Full crystallographic information is available from [OCA].
Reference
1.3 A structure of arylsulfatase from Pseudomonas aeruginosa establishes the catalytic mechanism of sulfate ester cleavage in the sulfatase family., Boltes I, Czapinska H, Kahnert A, von Bulow R, Dierks T, Schmidt B, von Figura K, Kertesz MA, Uson I, Structure. 2001 Jun;9(6):483-91. PMID:11435113
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