2j1x
From Proteopedia
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[[Image:2j1x.png|left|200px]] | [[Image:2j1x.png|left|200px]] | ||
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{{STRUCTURE_2j1x| PDB=2j1x | SCENE= }} | {{STRUCTURE_2j1x| PDB=2j1x | SCENE= }} | ||
===HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D=== | ===HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D=== | ||
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{{ABSTRACT_PUBMED_17015838}} | {{ABSTRACT_PUBMED_17015838}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2j1x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1X OCA]. | + | [[2j1x]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1X OCA]. |
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| + | ==See Also== | ||
| + | *[[P53|P53]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017015838</ref><ref group="xtra">PMID:014534297</ref><ref group="xtra">PMID:015703170</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fersht, A R.]] | [[Category: Fersht, A R.]] | ||
[[Category: Joerger, A C.]] | [[Category: Joerger, A C.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Anti-oncogene]] | [[Category: Anti-oncogene]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
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[[Category: P53 dna-binding domain]] | [[Category: P53 dna-binding domain]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Second-site suppressor mutation]] | [[Category: Second-site suppressor mutation]] | ||
[[Category: Superstable mutant]] | [[Category: Superstable mutant]] | ||
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[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
| - | [[Category: Zinc]] | ||
Revision as of 23:37, 26 July 2012
Contents |
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D
Template:ABSTRACT PUBMED 17015838
About this Structure
2j1x is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
- Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
Categories: Homo sapiens | Fersht, A R. | Joerger, A C. | Activator | Anti-oncogene | Apoptosis | Cell cycle | Disease mutation | Dna-binding | Dna-binding protein | Glycoprotein | Host-virus interaction | Li- fraumeni syndrome | Li-fraumeni syndrome | Metal-binding | Nuclear protein | P53 dna-binding domain | Phosphorylation | Second-site suppressor mutation | Superstable mutant | Transcription | Transcription regulation | Transferase | Tumor suppressor
