1cwl

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(New page: 200px<br /> <applet load="1cwl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cwl, resolution 1.80&Aring;" /> '''HUMAN CYCLOPHILIN A...)
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Revision as of 14:04, 29 October 2007

Image:1cwl.gif

1cwl, resolution 1.80Å

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HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN

Overview

Eight new X-ray structures of different cyclophilin, A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide, a useful structural database for the analysis of protein-ligand, interactions. The effect of small chemical differences on protein-ligand, hydrogen-bonding, van der Waals interactions and water structure is, presented.

About this Structure

1CWL is a [Single protein] structure of sequence from [Homo sapiens]. Active as [[1]], with EC number [5.2.1.8]. Full crystallographic information is available from [OCA].

Reference

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216

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