1fkn
From Proteopedia
(New page: 200px<br /> <applet load="1fkn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fkn, resolution 1.90Å" /> '''STRUCTURE OF BETA-S...) |
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| - | [[Image:1fkn.gif|left|200px]]<br /> | + | [[Image:1fkn.gif|left|200px]]<br /><applet load="1fkn" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1fkn" size=" | + | |
caption="1fkn, resolution 1.90Å" /> | caption="1fkn, resolution 1.90Å" /> | ||
'''STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR'''<br /> | '''STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease | + | Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity. |
==About this Structure== | ==About this Structure== | ||
| - | 1FKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http:// | + | 1FKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Terzyan, S.]] | [[Category: Terzyan, S.]] | ||
[[Category: Wu, S.]] | [[Category: Wu, S.]] | ||
| - | [[Category: Zhang, X | + | [[Category: Zhang, X C.]] |
[[Category: alzheimer's disease]] | [[Category: alzheimer's disease]] | ||
[[Category: aspartic protease]] | [[Category: aspartic protease]] | ||
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[[Category: memapsin 2]] | [[Category: memapsin 2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:39:41 2008'' |
Revision as of 10:39, 21 February 2008
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STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR
Overview
Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.
About this Structure
1FKN is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1FKN with [Amyloid-beta Precursor Protein]. Full crystallographic information is available from OCA.
Reference
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor., Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J, Science. 2000 Oct 6;290(5489):150-3. PMID:11021803
Page seeded by OCA on Thu Feb 21 12:39:41 2008
