1qiw
From Proteopedia
(New page: 200px<br /> <applet load="1qiw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qiw, resolution 2.30Å" /> '''CALMODULIN COMPLEXE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1QIW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CA and DPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QIW OCA]]. | + | 1QIW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CA and DPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: A1, A2, A3, A4, B1, B2, B3 and B4. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QIW OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: calcium-binding protein]] | [[Category: calcium-binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:03:26 2007'' |
Revision as of 11:58, 30 October 2007
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CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD)
Overview
An arylalkylamine-type calmodulin antagonist, N-(3, 3-diphenylpropyl)-N'-[1-R-(3, 4-bis-butoxyphenyl)ethyl]-propylene-diamine, (AAA) is presented and its complexes with calmodulin are characterized in, solution and in the crystal. Near-UV circular dichroism spectra show that, AAA binds to calmodulin with 2:1 stoichiometry in a Ca(2+)-dependent, manner. The crystal structure with 2:1 stoichiometry is determined to 2.64, A resolution. The binding of AAA causes domain closure of calmodulin, similar to that obtained with trifluoperazine. Solution and crystal data, indicate that each of the two AAA molecules anchors in the hydrophobic, pockets of calmodulin, overlapping with two trifluoperazine sites, i.e. at, a hydrophobic pocket and an interdomain site. The two AAA molecules also, interact ... [(full description)]
About this Structure
1QIW is a [Single protein] structure of sequence from [Bos taurus] with CA and DPD as [ligands]. Structure known Active Sites: A1, A2, A3, A4, B1, B2, B3 and B4. Full crystallographic information is available from [OCA].
Reference
A new potent calmodulin antagonist with arylalkylamine structure: crystallographic, spectroscopic and functional studies., Harmat V, Bocskei Z, Naray-Szabo G, Bata I, Csutor AS, Hermecz I, Aranyi P, Szabo B, Liliom K, Vertessy BG, Ovadi J, J Mol Biol. 2000 Mar 31;297(3):747-55. PMID:10731425
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