1fmq
From Proteopedia
(New page: 200px<br /><applet load="1fmq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fmq, resolution 2.Å" /> '''Cyclo-butyl-bis-furami...) |
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| - | [[Image:1fmq.gif|left|200px]]<br /><applet load="1fmq" size=" | + | [[Image:1fmq.gif|left|200px]]<br /><applet load="1fmq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1fmq, resolution 2.Å" /> | caption="1fmq, resolution 2.Å" /> | ||
'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''<br /> | '''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''<br /> | ||
==Overview== | ==Overview== | ||
| - | 2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and | + | 2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds. |
==About this Structure== | ==About this Structure== | ||
| - | 1FMQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG and D34 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1FMQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=D34:'>D34</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA]. |
==Reference== | ==Reference== | ||
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11128631 11128631] | DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11128631 11128631] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Boykin, D | + | [[Category: Boykin, D W.]] |
[[Category: Kumar, A.]] | [[Category: Kumar, A.]] | ||
[[Category: Lee, M.]] | [[Category: Lee, M.]] | ||
[[Category: Neidle, S.]] | [[Category: Neidle, S.]] | ||
| - | [[Category: Simpson, I | + | [[Category: Simpson, I J.]] |
[[Category: D34]] | [[Category: D34]] | ||
[[Category: MG]] | [[Category: MG]] | ||
[[Category: dna-drug minor groove complex]] | [[Category: dna-drug minor groove complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:17 2008'' |
Revision as of 10:40, 21 February 2008
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Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG
Overview
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
About this Structure
1FMQ is a Protein complex structure of sequences from [1] with and as ligands. Full crystallographic information is available from OCA.
Reference
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631
Page seeded by OCA on Thu Feb 21 12:40:17 2008
