3mpm
From Proteopedia
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[[Image:3mpm.png|left|200px]] | [[Image:3mpm.png|left|200px]] | ||
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{{STRUCTURE_3mpm| PDB=3mpm | SCENE= }} | {{STRUCTURE_3mpm| PDB=3mpm | SCENE= }} | ||
===LCK complexed with a pyrazolopyrimidine=== | ===LCK complexed with a pyrazolopyrimidine=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3mpm]] is a 1 chain structure of [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPM OCA]. | |
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| + | ==See Also== | ||
| + | *[[Tyrosine kinase|Tyrosine kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020483608</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
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[[Category: Kinase domain]] | [[Category: Kinase domain]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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Revision as of 00:41, 27 July 2012
Contents |
LCK complexed with a pyrazolopyrimidine
Template:ABSTRACT PUBMED 20483608
About this Structure
3mpm is a 1 chain structure of Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Gommermann N, Buehlmayer P, von Matt A, Breitenstein W, Masuya K, Pirard B, Furet P, Cowan-Jacob SW, Weckbecker G. New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3628-31. Epub 2010 Apr 29. PMID:20483608 doi:10.1016/j.bmcl.2010.04.112
