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1fnf
From Proteopedia
(New page: 200px<br /> <applet load="1fnf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fnf, resolution 2.0Å" /> '''FRAGMENT OF HUMAN FI...) |
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| - | [[Image:1fnf.gif|left|200px]]<br /> | + | [[Image:1fnf.gif|left|200px]]<br /><applet load="1fnf" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1fnf" size=" | + | |
caption="1fnf, resolution 2.0Å" /> | caption="1fnf, resolution 2.0Å" /> | ||
'''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10'''<br /> | '''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined the 2.0 A crystal structure of a fragment of human | + | We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1FNF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1FNF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Aukhil, I.]] | [[Category: Aukhil, I.]] | ||
| - | [[Category: Erickson, H | + | [[Category: Erickson, H P.]] |
| - | [[Category: Leahy, D | + | [[Category: Leahy, D J.]] |
[[Category: extracellular matrix]] | [[Category: extracellular matrix]] | ||
[[Category: rgd]] | [[Category: rgd]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:32 2008'' |
Revision as of 10:40, 21 February 2008
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FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Contents |
Overview
We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
Disease
Known diseases associated with this structure: Ehlers-Danlos syndrome, type X, 225310 (1) OMIM:[135600]
About this Structure
1FNF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Leahy DJ, Aukhil I, Erickson HP, Cell. 1996 Jan 12;84(1):155-64. PMID:8548820
Page seeded by OCA on Thu Feb 21 12:40:32 2008
