2gc8
From Proteopedia
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{{STRUCTURE_2gc8| PDB=2gc8 | SCENE= }} | {{STRUCTURE_2gc8| PDB=2gc8 | SCENE= }} | ||
===Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase=== | ===Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2gc8]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA]. | |
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| + | ==See Also== | ||
| + | *[[RNA polymerase|RNA polymerase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016722622</ref><references group="xtra"/> |
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
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[[Category: Connell, J O.]] | [[Category: Connell, J O.]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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Revision as of 01:30, 27 July 2012
Contents |
Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase
Template:ABSTRACT PUBMED 16722622
About this Structure
2gc8 is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem. 2006 Jun 1;49(11):3052-5. PMID:16722622 doi:10.1021/jm060168g
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Agarwal, A. | Bard, J. | Chopra, R. | Ciszewski, G. | Curran, K J. | Ellingboe, J W. | Feld, B. | Gopalsamy, A. | Howe, A Y. | Krishnamurthy, G. | Lim, K. | Mansour, T S. | Orlowski, M. | Shi, M. | Sukits, S F. | Svenson, K. | Connell, J O. | Transferase
