1o7i
From Proteopedia
(New page: 200px<br /> <applet load="1o7i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o7i, resolution 1.20Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1O7I is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O7I OCA]]. | + | 1O7I is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O7I OCA]]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: single stranded dna]] | [[Category: single stranded dna]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:04:31 2007'' |
Revision as of 11:59, 30 October 2007
|
CRYSTAL STRUCTURE OF A SINGLE STRANDED DNA BINDING PROTEIN
Overview
Information processing pathways such as DNA replication are conserved in, eukaryotes and archaea and are significantly different from those found in, bacteria. Single-stranded DNA-binding (SSB) proteins (or replication, protein A, RPA, in eukaryotes) play a central role in many of these, pathways. However, whilst euryarchaea have a eukaryotic-type RPA, homologue, crenarchaeal SSB proteins appear much more similar to the, bacterial proteins, with a single OB fold for DNA binding and a flexible, C-terminal tail that is implicated in protein-protein interactions. We, have determined the crystal structure of the SSB protein from the, crenarchaeote Sulfolobus solfataricus to 1.26 A. The structure shows a, striking and unexpected similarity to the DNA-binding domains of human, RPA, providing ... [(full description)]
About this Structure
1O7I is a [Single protein] structure of sequence from [Sulfolobus solfataricus] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein., Kerr ID, Wadsworth RI, Cubeddu L, Blankenfeldt W, Naismith JH, White MF, EMBO J. 2003 Jun 2;22(11):2561-70. PMID:12773373
Page seeded by OCA on Tue Oct 30 14:04:31 2007
