1zpc

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[[Image:1zpc.png|left|200px]]
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{{STRUCTURE_1zpc| PDB=1zpc | SCENE= }}
{{STRUCTURE_1zpc| PDB=1zpc | SCENE= }}
===Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide===
===Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide===
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{{ABSTRACT_PUBMED_16524727}}
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==Disease==
 
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Known disease associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]], Factor XI deficiency, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264900 264900]]
 
==About this Structure==
==About this Structure==
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1ZPC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPC OCA].
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[[1zpc]] is a 1 chain structure of [[Factor XIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPC OCA].
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==See Also==
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*[[Factor XIa|Factor XIa]]
==Reference==
==Reference==
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<ref group="xtra">PMID:16524727</ref><references group="xtra"/>
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<ref group="xtra">PMID:016524727</ref><references group="xtra"/>
[[Category: Coagulation factor XIa]]
[[Category: Coagulation factor XIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Strickler, J E.]]
[[Category: Strickler, J E.]]
[[Category: Fxi]]
[[Category: Fxi]]
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[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:52:32 2009''
 

Revision as of 02:20, 27 July 2012

Image:1zpc.png

Template:STRUCTURE 1zpc

Contents

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide

Template:ABSTRACT PUBMED 16524727

About this Structure

1zpc is a 1 chain structure of Factor XIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE. Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9. PMID:16524727 doi:http://dx.doi.org/10.1016/j.bmcl.2006.02.052

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OCA

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