2ic3

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[[Image:2ic3.png|left|200px]]
[[Image:2ic3.png|left|200px]]
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{{STRUCTURE_2ic3| PDB=2ic3 | SCENE= }}
{{STRUCTURE_2ic3| PDB=2ic3 | SCENE= }}
===Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097===
===Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097===
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{{ABSTRACT_PUBMED_17056061}}
{{ABSTRACT_PUBMED_17056061}}
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==See Also==
==See Also==
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*[[Reverse transcriptase]]
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*[[Reverse transcriptase|Reverse transcriptase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:17056061</ref><ref group="xtra">PMID:8805568</ref><ref group="xtra">PMID:9000632</ref><ref group="xtra">PMID:9813120</ref><ref group="xtra">PMID:11371163</ref><ref group="xtra">PMID:15115397</ref><references group="xtra"/>
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<ref group="xtra">PMID:017056061</ref><ref group="xtra">PMID:008805568</ref><ref group="xtra">PMID:009000632</ref><ref group="xtra">PMID:009813120</ref><ref group="xtra">PMID:011371163</ref><ref group="xtra">PMID:015115397</ref><references group="xtra"/>
[[Category: Human immunodeficiency virus type 1 bh10]]
[[Category: Human immunodeficiency virus type 1 bh10]]
[[Category: RNA-directed DNA polymerase]]
[[Category: RNA-directed DNA polymerase]]

Revision as of 02:54, 27 July 2012

Image:2ic3.png

Template:STRUCTURE 2ic3

Contents

Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097

Template:ABSTRACT PUBMED 17056061

About this Structure

2ic3 is a 2 chain structure of Reverse transcriptase with sequence from Human immunodeficiency virus type 1 bh10. Full crystallographic information is available from OCA.

See Also

Reference

  • Das K, Sarafianos SG, Clark AD Jr, Boyer PL, Hughes SH, Arnold E. Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. J Mol Biol. 2007 Jan 5;365(1):77-89. Epub 2006 Sep 15. PMID:17056061 doi:10.1016/j.jmb.2006.08.097
  • Hsiou Y, Ding J, Das K, Clark AD Jr, Hughes SH, Arnold E. Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure. 1996 Jul 15;4(7):853-60. PMID:8805568
  • Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E. Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant. J Mol Biol. 1996 Dec 20;264(5):1085-100. PMID:9000632
  • Hsiou Y, Das K, Ding J, Clark AD Jr, Kleim JP, Rosner M, Winkler I, Riess G, Hughes SH, Arnold E. Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance. J Mol Biol. 1998 Nov 27;284(2):313-23. PMID:9813120 doi:10.1006/jmbi.1998.2171
  • Hsiou Y, Ding J, Das K, Clark AD Jr, Boyer PL, Lewi P, Janssen PA, Kleim JP, Rosner M, Hughes SH, Arnold E. The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. J Mol Biol. 2001 Jun 1;309(2):437-45. PMID:11371163 doi:10.1006/jmbi.2001.4648
  • Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, Andries K, Pauwels R, De Bethune MP, Boyer PL, Clark P, Hughes SH, Janssen PA, Arnold E. Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. J Med Chem. 2004 May 6;47(10):2550-60. PMID:15115397 doi:http://dx.doi.org/10.1021/jm030558s

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