1g0x
From Proteopedia
(New page: 200px<br /> <applet load="1g0x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g0x, resolution 2.10Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1g0x.gif|left|200px]]<br /> | + | [[Image:1g0x.gif|left|200px]]<br /><applet load="1g0x" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1g0x" size=" | + | |
caption="1g0x, resolution 2.10Å" /> | caption="1g0x, resolution 2.10Å" /> | ||
'''CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF LIR-1 (ILT2)'''<br /> | '''CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF LIR-1 (ILT2)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | LIR-1 is an inhibitory receptor that recognizes class I MHC molecules and | + | LIR-1 is an inhibitory receptor that recognizes class I MHC molecules and the human cytomegalovirus class I homolog UL18. Here, we report the 2.1 A resolution crystal structure of the ligand binding portion of LIR-1 (domains 1 and 2 [D1D2]) and localize the binding region for UL18. LIR-1 D1D2 is composed of two immunoglobulin-like domains arranged at an acute angle to form a bent structure resembling the structures of natural killer inhibitory receptors (KIRs). The LIR-1 binding site comprises a portion of D1 distant from the interdomain hinge region that constitutes the KIR binding site, consistent with differences in LIR-1 and KIR recognition properties and functions. |
==About this Structure== | ==About this Structure== | ||
| - | 1G0X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1G0X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G0X OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bjorkman, P | + | [[Category: Bjorkman, P J.]] |
| - | [[Category: Chapman, T | + | [[Category: Chapman, T L.]] |
| - | [[Category: Heikema, A | + | [[Category: Heikema, A P.]] |
| - | [[Category: Jr., A | + | [[Category: Jr., A P.West.]] |
[[Category: 3-10 helix]] | [[Category: 3-10 helix]] | ||
[[Category: immunoglobulin fold]] | [[Category: immunoglobulin fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:44:47 2008'' |
Revision as of 10:44, 21 February 2008
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CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF LIR-1 (ILT2)
Overview
LIR-1 is an inhibitory receptor that recognizes class I MHC molecules and the human cytomegalovirus class I homolog UL18. Here, we report the 2.1 A resolution crystal structure of the ligand binding portion of LIR-1 (domains 1 and 2 [D1D2]) and localize the binding region for UL18. LIR-1 D1D2 is composed of two immunoglobulin-like domains arranged at an acute angle to form a bent structure resembling the structures of natural killer inhibitory receptors (KIRs). The LIR-1 binding site comprises a portion of D1 distant from the interdomain hinge region that constitutes the KIR binding site, consistent with differences in LIR-1 and KIR recognition properties and functions.
About this Structure
1G0X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2)., Chapman TL, Heikema AP, West AP Jr, Bjorkman PJ, Immunity. 2000 Nov;13(5):727-36. PMID:11114384
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