2bka
From Proteopedia
(New page: 200px<br /> <applet load="2bka" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bka, resolution 1.70Å" /> '''CC3(TIP30)CRYSTAL S...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BKA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, NDP, PE8 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKA OCA]]. | + | 2BKA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, NDP, PE8 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKA OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transcription]] | [[Category: transcription]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:06:09 2007'' |
Revision as of 12:01, 30 October 2007
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CC3(TIP30)CRYSTAL STRUCURE
Overview
CC3 (TIP30) is a protein with pro-apoptotic and anti-metastatic, properties. The tumor suppressor effect of CC3 has been suggested to, result from inhibition of nuclear transport by binding to importin betas, or by regulating transcription through interaction in a complex with, co-activator independent of AF-2 function (CIA) and the c-myc gene., Previous biochemical studies indicated that CC3 has protein kinase, activity, and a structural similarity to cAMP-dependent protein kinase, catalytic subunit was proposed. By contrast, bioinformatics studies, suggested a relationship of CC3 to the short chain dehydrogenase reductase, family. To clarify details of the CC3 structural family and ligand binding, properties, we have determined the crystal structure of CC3 at 1.7-A, resolution. CC3 has ... [(full description)]
About this Structure
2BKA is a [Single protein] structure of sequence from [Homo sapiens] with SO4, NDP, PE8 and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor., El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK, J Biol Chem. 2005 May 6;280(18):18229-36. Epub 2005 Feb 22. PMID:15728189
Page seeded by OCA on Tue Oct 30 14:06:09 2007
Categories: Homo sapiens | Single protein | Bird, L.E. | Nichols, C.E. | Omari, K.El. | Ren, J. | Stammers, D.K. | GOL | NDP | PE8 | SO4 | Cc3 | Nadph | Peg600 | Tip30 | Transcription
