2bky
From Proteopedia
(New page: 200px<br /> <applet load="2bky" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bky, resolution 1.70Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BKY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with MPD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKY OCA]]. | + | 2BKY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with MPD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKY OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: rna-binding]] | [[Category: rna-binding]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:06:21 2007'' |
Revision as of 12:01, 30 October 2007
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CRYSTAL STRUCTURE OF THE ALBA1:ALBA2 HETERODIMER FROM SULFOLOBUS SOLFATARICUS
Overview
Organisms growing at elevated temperatures face a particular challenge to, maintain the integrity of their genetic material. All thermophilic and, hyperthermophilic archaea encode one or more copies of the Alba (Sac10b), gene. Alba is an abundant, dimeric, highly basic protein that binds, cooperatively and at high density to DNA. Sulfolobus solfataricus encodes, a second copy of the Alba gene, and the Alba2 protein is expressed at, approximately 5% of the level of Alba1. We demonstrate by NMR, ITC, and, crystallography that Alba2 exists exclusively as a heterodimer with Alba1, at physiological concentrations and that heterodimerization exerts a clear, effect upon the DNA packaging, as observed by EM, potentially by changing, the interface between adjacent Alba dimers in DNA complexes. A ... [(full description)]
About this Structure
2BKY is a [Protein complex] structure of sequences from [Sulfolobus solfataricus] with MPD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Obligate heterodimerization of the archaeal Alba2 protein with Alba1 provides a mechanism for control of DNA packaging., Jelinska C, Conroy MJ, Craven CJ, Hounslow AM, Bullough PA, Waltho JP, Taylor GL, White MF, Structure. 2005 Jul;13(7):963-71. PMID:16004869
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