1g61
From Proteopedia
(New page: 200px<br /><applet load="1g61" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g61, resolution 1.3Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1g61.gif|left|200px]]<br /><applet load="1g61" size=" | + | [[Image:1g61.gif|left|200px]]<br /><applet load="1g61" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1g61, resolution 1.3Å" /> | caption="1g61, resolution 1.3Å" /> | ||
'''CRYSTAL STRUCTURE OF M.JANNASCHII EIF6'''<br /> | '''CRYSTAL STRUCTURE OF M.JANNASCHII EIF6'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Ribosome anti-association factor eIF6 (originally named according to | + | Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit. |
==About this Structure== | ==About this Structure== | ||
| - | 1G61 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http:// | + | 1G61 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G61 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Beckmann, R.]] | [[Category: Beckmann, R.]] | ||
| - | [[Category: Burley, S | + | [[Category: Burley, S K.]] |
| - | [[Category: Groft, C | + | [[Category: Groft, C M.]] |
| - | [[Category: NYSGXRC, New | + | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]] |
[[Category: Sali, A.]] | [[Category: Sali, A.]] | ||
[[Category: alpha-beta-barrel velcro closure subdomain]] | [[Category: alpha-beta-barrel velcro closure subdomain]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:30 2008'' |
Revision as of 10:46, 21 February 2008
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CRYSTAL STRUCTURE OF M.JANNASCHII EIF6
Overview
Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.
About this Structure
1G61 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Reference
Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899
Page seeded by OCA on Thu Feb 21 12:46:30 2008
Categories: Methanocaldococcus jannaschii | Single protein | Beckmann, R. | Burley, S K. | Groft, C M. | NYSGXRC, New York Structural GenomiX Research Consortium. | Sali, A. | Alpha-beta-barrel velcro closure subdomain | New york structural genomix research consortium | Nysgxrc | Protein structure initiative | Psi | Structural genomics
