1gcn
From Proteopedia
(New page: 200px<br /><applet load="1gcn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gcn, resolution 3.0Å" /> '''X-RAY ANALYSIS OF GLU...) |
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| - | [[Image:1gcn.gif|left|200px]]<br /><applet load="1gcn" size=" | + | [[Image:1gcn.gif|left|200px]]<br /><applet load="1gcn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gcn, resolution 3.0Å" /> | caption="1gcn, resolution 3.0Å" /> | ||
'''X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING'''<br /> | '''X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING'''<br /> | ||
==Overview== | ==Overview== | ||
| - | X-ray analysis of the pancreatic hormone glucagon shows that in crystals | + | X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor. |
==About this Structure== | ==About this Structure== | ||
| - | 1GCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http:// | + | 1GCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Blundell, T | + | [[Category: Blundell, T L.]] |
[[Category: Dockerill, S.]] | [[Category: Dockerill, S.]] | ||
[[Category: Sasaki, K.]] | [[Category: Sasaki, K.]] | ||
| - | [[Category: Tickle, I | + | [[Category: Tickle, I J.]] |
[[Category: hormone]] | [[Category: hormone]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:48:42 2008'' |
Revision as of 10:48, 21 February 2008
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X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING
Overview
X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor.
About this Structure
1GCN is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
X-ray analysis of glucagon and its relationship to receptor binding., Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T, Nature. 1975 Oct 30;257(5529):751-7. PMID:171582
Page seeded by OCA on Thu Feb 21 12:48:42 2008
