3tk3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:3tk3.png|left|200px]]
[[Image:3tk3.png|left|200px]]
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3tk3", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3tk3| PDB=3tk3 | SCENE= }}
{{STRUCTURE_3tk3| PDB=3tk3 | SCENE= }}
===Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole===
===Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole===
- 
-
<!--
 
-
The line below this paragraph, {{ABSTRACT_PUBMED_22051155}}, adds the Publication Abstract to the page
 
-
(as it appears on PubMed at http://www.pubmed.gov), where 22051155 is the PubMed ID number.
 
-
-->
 
{{ABSTRACT_PUBMED_22051155}}
{{ABSTRACT_PUBMED_22051155}}
==About this Structure==
==About this Structure==
-
[[3tk3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK3 OCA].
+
[[3tk3]] is a 4 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TK3 OCA].
 +
 
 +
==See Also==
 +
*[[Cytochrome P450|Cytochrome P450]]
==Reference==
==Reference==

Revision as of 06:36, 27 July 2012

Image:3tk3.png

Template:STRUCTURE 3tk3

Contents

Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole

Template:ABSTRACT PUBMED 22051155

About this Structure

3tk3 is a 4 chain structure of Cytochrome P450 with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

See Also

Reference

  • Wilderman PR, Gay SC, Jang HH, Zhang Q, Stout CD, Halpert JR. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme. FEBS J. 2011 Nov 3. doi: 10.1111/j.1742-4658.2011.08411.x. PMID:22051155 doi:10.1111/j.1742-4658.2011.08411.x
  • Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD. Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. J Biol Chem. 2006 Mar 3;281(9):5973-81. Epub 2005 Dec 21. PMID:16373351 doi:10.1074/jbc.M511464200
  • Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. J Biol Chem. 2004 Jun 25;279(26):27294-301. Epub 2004 Apr 20. PMID:15100217 doi:10.1074/jbc.M403349200
  • Scott EE, He YA, Wester MR, White MA, Chin CC, Halpert JR, Johnson EF, Stout CD. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13196-201. Epub 2003 Oct 16. PMID:14563924 doi:http://dx.doi.org/10.1073/pnas.2133986100
  • Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR. Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4. Biochemistry. 2007 Oct 16;46(41):11559-67. Epub 2007 Sep 22. PMID:17887776 doi:http://dx.doi.org/10.1021/bi7011614
  • Gay SC, Sun L, Maekawa K, Halpert JR, Stout CD. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1Himidazole: ligand induced structural response through -helical repositioning. Biochemistry. 2009 Apr 27. PMID:19397311 doi:10.1021/bi9003765
  • Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 2010 Oct 12;49(40):8709-20. Epub 2010 Sep 15. PMID:20815363 doi:10.1021/bi100914z
  • Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL Jr, Stout CD, Halpert JR. Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography. J Biol Chem. 2010 Dec 3;285(49):38602-11. Epub 2010 Sep 28. PMID:20880847 doi:10.1074/jbc.M110.180646
  • Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL, Stout CD, Hollenberg PF, Halpert JR. Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity. Biochemistry. 2011 Apr 21. PMID:21510666 doi:10.1021/bi200482g

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3tk3"
Personal tools