2r4f
From Proteopedia
(Difference between revisions)
m (Protected "2r4f" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
[[Image:2r4f.png|left|200px]] | [[Image:2r4f.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2r4f", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2r4f| PDB=2r4f | SCENE= }} | {{STRUCTURE_2r4f| PDB=2r4f | SCENE= }} | ||
===Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors=== | ===Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_18072721}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18072721 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_18072721}} | {{ABSTRACT_PUBMED_18072721}} | ||
| Line 22: | Line 11: | ||
==See Also== | ==See Also== | ||
| - | *[[HMG-CoA Reductase]] | + | *[[HMG-CoA Reductase|HMG-CoA Reductase]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018072721</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Finzel, B C.]] | [[Category: Finzel, B C.]] | ||
| Line 31: | Line 20: | ||
[[Category: Pavlovsky, A.]] | [[Category: Pavlovsky, A.]] | ||
[[Category: Pfefferkorn, J A.]] | [[Category: Pfefferkorn, J A.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Biocynthesis]] | [[Category: Biocynthesis]] | ||
[[Category: Cholesterol]] | [[Category: Cholesterol]] | ||
| Line 43: | Line 31: | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Peroxisome]] | [[Category: Peroxisome]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Statin]] | [[Category: Statin]] | ||
[[Category: Steroid biosynthesis]] | [[Category: Steroid biosynthesis]] | ||
[[Category: Sterol biosynthesis]] | [[Category: Sterol biosynthesis]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
Revision as of 06:51, 27 July 2012
Contents |
Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors
Template:ABSTRACT PUBMED 18072721
About this Structure
2r4f is a 4 chain structure of HMG-CoA Reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721 doi:10.1021/jm070849r
Categories: Homo sapiens | Finzel, B C. | Harris, M S. | Pavlovsky, A. | Pfefferkorn, J A. | Biocynthesis | Cholesterol | Cholesterol biosynthesis | Endoplasmic reticulum | Glycoprotein | Hmg-coa | Lipid synthesis | Membrane | Nadph | Oxidoreductase | Peroxisome | Statin | Steroid biosynthesis | Sterol biosynthesis | Transmembrane
