3igb

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Revision as of 07:07, 27 July 2012

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Template:STRUCTURE 3igb

Contents 1 Bace-1 with Compound 3 2 About this Structure 3 See Also 4 Reference

Bace-1 with Compound 3

Template:ABSTRACT PUBMED 19757823

About this Structure

3igb is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Malamas MS, Erdei J, Gunawan I, Barnes K, Johnson M, Hui Y, Turner J, Hu Y, Wagner E, Fan K, Olland A, Bard J, Robichaud AJ. Aminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors. J Med Chem. 2009 Oct 22;52(20):6314-23. PMID:19757823 doi:10.1021/jm9006752
• Malamas MS, Erdei J, Gunawan I, Turner J, Hu Y, Wagner E, Fan K, Chopra R, Olland A, Bard J, Jacobsen S, Magolda RL, Pangalos M, Robichaud AJ. Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors. J Med Chem. 2010 Feb 11;53(3):1146-58. PMID:19968289 doi:10.1021/jm901414e