1ghq
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B | + | Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design. |
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Chen, X | + | [[Category: Chen, X S.]] |
| - | [[Category: Guthridge, J | + | [[Category: Guthridge, J M.]] |
| - | [[Category: Holers, V | + | [[Category: Holers, V M.]] |
[[Category: Li, D.]] | [[Category: Li, D.]] | ||
[[Category: Szakonyi, G.]] | [[Category: Szakonyi, G.]] | ||
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[[Category: cr2]] | [[Category: cr2]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:50:13 2008'' |
Revision as of 10:50, 21 February 2008
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CR2-C3D COMPLEX STRUCTURE
Contents |
Overview
Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.
Disease
Known diseases associated with this structure: C3 deficiency OMIM:[120700], Macular degeneration, age-related, 9 OMIM:[120700], Systemic lupus erythematosus, susceptibility to, 9 OMIM:[120650]
About this Structure
1GHQ is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of complement receptor 2 in complex with its C3d ligand., Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS, Science. 2001 Jun 1;292(5522):1725-8. PMID:11387479
Page seeded by OCA on Thu Feb 21 12:50:13 2008
Categories: Homo sapiens | Protein complex | Chen, X S. | Guthridge, J M. | Holers, V M. | Li, D. | Szakonyi, G. | NDG | ZN | C3d | Cr2
