1o5g
From Proteopedia
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===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)=== | ===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[1o5g]] is a 3 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5G OCA]. | + | [[1o5g]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5G OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Hirudin]] | + | *[[Hirudin|Hirudin]] |
| + | *[[Thrombin|Thrombin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015522303</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
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[[Category: Hepsin]] | [[Category: Hepsin]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Hydrolase-inhibitor complex]] | ||
[[Category: S1 site]] | [[Category: S1 site]] | ||
[[Category: Selectivity]] | [[Category: Selectivity]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Trypsin]] | [[Category: Trypsin]] | ||
Revision as of 07:38, 27 July 2012
Contents |
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Template:ABSTRACT PUBMED 15522303
About this Structure
1o5g is a 3 chain structure of Hirudin and Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol. 2004 Nov 19;344(2):527-47. PMID:15522303 doi:10.1016/j.jmb.2004.09.032
Categories: Homo sapiens | Thrombin | Chan, H. | Gjerstad, E. | Ho, J D. | Janc, J W. | Katz, B A. | Luong, C. | Mackman, R L. | McGrath, M E. | Mortara, K. | Somoza, J R. | Sprengeler, P A. | Tang, J. | Verner, E. | Williams, S R. | Young, W B. | Ala190 upa | Blood clotting | Conserved water displacement hydrogen bond deficit | Factor viia | Hepsin | Hydrolase | Hydrolase-hydrolase inhibitor complex | Hydrolase-inhibitor complex | S1 site | Selectivity | Trypsin
