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Revision as of 08:23, 27 July 2012

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spinqualitylabelsall models PDB ID 1opl Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1opl, resolution 3.42Å ()
Ligands:	,
Gene:	Abl (Homo sapiens)
Activity:	Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Related:	1opj, 1opk
Structural annotation: Resources: CATH : 1Opla04, 1Opla03, 1Opla02, 1Opla01 InterPro : Ipr011009, Ipr008266, Ipr015015, Ipr001245, Ipr000980, Ipr000719, Ipr001452 Pfam : PF07714, PF00018, PF00017 SCOP : d1opla3, d1opla2, d1opla1, d1oplb1, d1oplb2 UniProt : P00519
Functional annotation: Cellular component: cytoskeleton cytoplasm nucleus Biological process: protein amino acid phosphorylation DNA damage response, signal transduction resulting in induction of apoptosis intracellular signaling cascade S-phase-specific transcription in mitotic cell cycle cell adhesion actin cytoskeleton organization and biogenesis mismatch repair regulation of transcription, DNA-dependent peptidyl-tyrosine phosphorylation protein modification process Molecular function: transferase activity protein C-terminus binding nucleotide binding kinase activity metal ion binding manganese ion binding magnesium ion binding protein kinase activity ATP binding protein-tyrosine kinase activity DNA binding protein binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Structural basis for the auto-inhibition of c-Abl tyrosine kinase 2 About this Structure 3 See Also 4 Reference

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Template:ABSTRACT PUBMED 12654251

About this Structure

1opl is a 2 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Homo sapiens. The July 2003 RCSB PDB Molecule of the Month feature on Src Tyrosine Kinase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2003_7. Full crystallographic information is available from OCA.

See Also

• Proto-oncogene tyrosine-protein kinase

Reference

• Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J. Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell. 2003 Mar 21;112(6):859-71. PMID:12654251