1gp3
From Proteopedia
(New page: 200px<br /> <applet load="1gp3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gp3, resolution 1.95Å" /> '''HUMAN IGF2R DOMAIN ...) |
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caption="1gp3, resolution 1.95Å" /> | caption="1gp3, resolution 1.95Å" /> | ||
'''HUMAN IGF2R DOMAIN 11'''<br /> | '''HUMAN IGF2R DOMAIN 11'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Insulin-like growth factor II receptor (IGF2R) is a multifunctional cell | + | Insulin-like growth factor II receptor (IGF2R) is a multifunctional cell surface receptor implicated in tumour suppression. Its growth inhibitory activity has been associated with an ability to bind IGF-II. IGF2R contains 15 homologous extracellular domains, with domain 11 primarily responsible for IGF-II binding. We report a 1.4 A resolution crystal structure of domain 11, solved using the anomalous scattering signal of sulfur. The structure consists of two crossed beta-sheets forming a flattened beta-barrel. Structural analysis identifies the putative IGF-II binding site at one end of the beta-barrel whilst crystal lattice contacts suggest a model for the full-length IGF2R extracellular region. The structure factors and coordinates of IGF2R domain 11 have been deposited in the Protein Data Bank (accession codes 1GP0 and 1GP3). |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GP3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1GP3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GP3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Brown, J.]] | [[Category: Brown, J.]] | ||
| - | [[Category: Esnouf, R | + | [[Category: Esnouf, R M.]] |
[[Category: Harlos, K.]] | [[Category: Harlos, K.]] | ||
| - | [[Category: Hassan, A | + | [[Category: Hassan, A B.]] |
| - | [[Category: Jones, E | + | [[Category: Jones, E Y.]] |
| - | [[Category: Jones, M | + | [[Category: Jones, M A.]] |
[[Category: Linnell, J.]] | [[Category: Linnell, J.]] | ||
[[Category: beta barrel]] | [[Category: beta barrel]] | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:52:27 2008'' |
Revision as of 10:52, 21 February 2008
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HUMAN IGF2R DOMAIN 11
Contents |
Overview
Insulin-like growth factor II receptor (IGF2R) is a multifunctional cell surface receptor implicated in tumour suppression. Its growth inhibitory activity has been associated with an ability to bind IGF-II. IGF2R contains 15 homologous extracellular domains, with domain 11 primarily responsible for IGF-II binding. We report a 1.4 A resolution crystal structure of domain 11, solved using the anomalous scattering signal of sulfur. The structure consists of two crossed beta-sheets forming a flattened beta-barrel. Structural analysis identifies the putative IGF-II binding site at one end of the beta-barrel whilst crystal lattice contacts suggest a model for the full-length IGF2R extracellular region. The structure factors and coordinates of IGF2R domain 11 have been deposited in the Protein Data Bank (accession codes 1GP0 and 1GP3).
Disease
Known diseases associated with this structure: Hepatocellular carcinoma OMIM:[147280]
About this Structure
1GP3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur., Brown J, Esnouf RM, Jones MA, Linnell J, Harlos K, Hassan AB, Jones EY, EMBO J. 2002 Mar 1;21(5):1054-62. PMID:11867533
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