3juh
From Proteopedia
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===Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity=== | ===Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity=== | ||
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==See Also== | ==See Also== | ||
| - | *[[Casein kinase]] | + | *[[Casein kinase|Casein kinase]] |
==Reference== | ==Reference== | ||
Revision as of 08:58, 27 July 2012
Contents |
Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity
Template:ABSTRACT PUBMED 15740749
About this Structure
3juh is a 2 chain structure of Casein kinase with sequence from Homo sapiens. This structure supersedes the now removed PDB entries and 1ymi. Full crystallographic information is available from OCA.
See Also
Reference
- Yde CW, Ermakova I, Issinger OG, Niefind K. Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. J Mol Biol. 2005 Mar 25;347(2):399-414. Epub 2005 Jan 18. PMID:15740749 doi:http://dx.doi.org/10.1016/j.jmb.2005.01.003
- Raaf J, Brunstein E, Issinger OG, Niefind K. The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules. Chem Biol. 2008 Feb;15(2):111-7. PMID:18291315 doi:http://dx.doi.org/10.1016/j.chembiol.2007.12.012
- Niefind K, Issinger OG. Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design. Biochim Biophys Acta. 2010 Mar;1804(3):484-92. Epub 2009 Sep 28. PMID:19796713 doi:10.1016/j.bbapap.2009.09.022
- Niefind K, Raaf J, Issinger OG. Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights. Cell Mol Life Sci. 2009 Jun;66(11-12):1800-16. PMID:19387553 doi:10.1007/s00018-009-9149-8
