1gri
From Proteopedia
(New page: 200px<br /> <applet load="1gri" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gri, resolution 3.1Å" /> '''GRB2'''<br /> ==Ove...) |
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caption="1gri, resolution 3.1Å" /> | caption="1gri, resolution 3.1Å" /> | ||
'''GRB2'''<br /> | '''GRB2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The mammalian growth factor receptor-binding protein Grb2 is an adaptor | + | The mammalian growth factor receptor-binding protein Grb2 is an adaptor that mediates activation of guanine nucleotide exchange on Ras. Grb2 binds to the receptor through its SH2 domain and to the carboxyl-terminal domain of Son of sevenless through its two SH3 domains. It is thus a key element in the signal transduction pathway. The crystal structure of Grb2 was determined to 3.1 angstrom resolution. The asymmetric unit is composed of an embedded dimer. The interlaced junctions between the SH2 and SH3 domains bring the two adjacent faces of the SH3 domains in van der Waals contact but leave room for the binding of proline-rich peptides. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GRI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1GRI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GRI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sh3]] | [[Category: sh3]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:53:11 2008'' |
Revision as of 10:53, 21 February 2008
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GRB2
Contents |
Overview
The mammalian growth factor receptor-binding protein Grb2 is an adaptor that mediates activation of guanine nucleotide exchange on Ras. Grb2 binds to the receptor through its SH2 domain and to the carboxyl-terminal domain of Son of sevenless through its two SH3 domains. It is thus a key element in the signal transduction pathway. The crystal structure of Grb2 was determined to 3.1 angstrom resolution. The asymmetric unit is composed of an embedded dimer. The interlaced junctions between the SH2 and SH3 domains bring the two adjacent faces of the SH3 domains in van der Waals contact but leave room for the binding of proline-rich peptides.
Disease
Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[100790], Haddad syndrome OMIM:[100790]
About this Structure
1GRI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the mammalian Grb2 adaptor., Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A, Science. 1995 Apr 14;268(5208):291-3. PMID:7716522
Page seeded by OCA on Thu Feb 21 12:53:11 2008
Categories: Homo sapiens | Single protein | Arnoux, B. | Ducruix, A. | Maignan, S. | Sh2 | Sh3
