1gsm
From Proteopedia
(New page: 200px<br /><applet load="1gsm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gsm, resolution 1.90Å" /> '''A REASSESSMENT OF TH...) |
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| - | [[Image:1gsm.gif|left|200px]]<br /><applet load="1gsm" size=" | + | [[Image:1gsm.gif|left|200px]]<br /><applet load="1gsm" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1gsm, resolution 1.90Å" /> | caption="1gsm, resolution 1.90Å" /> | ||
'''A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.'''<br /> | '''A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Mucosal addressin cell-adhesion molecule (MAdCAM-1) is a membrane-bound | + | Mucosal addressin cell-adhesion molecule (MAdCAM-1) is a membrane-bound leukocyte receptor regulating both the passage and retention of leukocytes in mucosal tissues. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1 has previously been reported, confirming their expected immunoglobulin superfamily topology. In this study, a second crystal structure of this fragment is described. Although the overall structure is similar to that previously reported, one edge strand in the amino-terminal domain is instead located on the opposite sheet. This alters the arrangement and conformation of amino acids in this region that have previously been shown to be crucial for ligand binding. MAdCAM-1 is also seen to form dimers within the crystal lattice, raising the possibility that oligomerization may influence the biological role of this adhesion molecule. |
==About this Structure== | ==About this Structure== | ||
| - | 1GSM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1GSM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Brady, R | + | [[Category: Brady, R L.]] |
[[Category: Dando, J.]] | [[Category: Dando, J.]] | ||
| - | [[Category: King, D | + | [[Category: King, D J.]] |
[[Category: Ortlepp, S.]] | [[Category: Ortlepp, S.]] | ||
| - | [[Category: Wilkinson, K | + | [[Category: Wilkinson, K W.]] |
[[Category: cell adhesion glycoprotein]] | [[Category: cell adhesion glycoprotein]] | ||
[[Category: cell adhesion protein]] | [[Category: cell adhesion protein]] | ||
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[[Category: membrane protein]] | [[Category: membrane protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:53:32 2008'' |
Revision as of 10:53, 21 February 2008
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A REASSESSMENT OF THE MADCAM-1 STRUCTURE AND ITS ROLE IN INTEGRIN RECOGNITION.
Overview
Mucosal addressin cell-adhesion molecule (MAdCAM-1) is a membrane-bound leukocyte receptor regulating both the passage and retention of leukocytes in mucosal tissues. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1 has previously been reported, confirming their expected immunoglobulin superfamily topology. In this study, a second crystal structure of this fragment is described. Although the overall structure is similar to that previously reported, one edge strand in the amino-terminal domain is instead located on the opposite sheet. This alters the arrangement and conformation of amino acids in this region that have previously been shown to be crucial for ligand binding. MAdCAM-1 is also seen to form dimers within the crystal lattice, raising the possibility that oligomerization may influence the biological role of this adhesion molecule.
About this Structure
1GSM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A reassessment of the MAdCAM-1 structure and its role in integrin recognition., Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Feb;58(Pt 2):233-41. Epub 2002, Jan 24. PMID:11807247
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