5p21

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[[Image:5p21.png|left|200px]]
[[Image:5p21.png|left|200px]]
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{{STRUCTURE_5p21| PDB=5p21 | SCENE= }}
{{STRUCTURE_5p21| PDB=5p21 | SCENE= }}
===REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS===
===REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS===
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{{ABSTRACT_PUBMED_2196171}}
{{ABSTRACT_PUBMED_2196171}}
==About this Structure==
==About this Structure==
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[[5p21]] is a 1 chain structure of [[HRAS p21]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2012 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ras Protein'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2012_4 10.2210/rcsb_pdb/mom_2012_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5P21 OCA].
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[[5p21]] is a 1 chain structure of [[GTPase HRas]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The April 2012 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ras Protein'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2012_4 10.2210/rcsb_pdb/mom_2012_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5P21 OCA].
==See Also==
==See Also==
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*[[HRAS p21|HRAS p21]]
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*[[GTPase HRas|GTPase HRas]]
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*[[Structural templates|Structural templates]]
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*[[User:James D Watson/Proteins Intro|User:James D Watson/Proteins Intro]]
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*[[User:James D Watson/Structural Templates|User:James D Watson/Structural Templates]]
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*[[User:Joseph Lipsick/RAS|User:Joseph Lipsick/RAS]]
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==Reference==
==Reference==

Revision as of 10:36, 27 July 2012

Image:5p21.png


PDB ID 5p21

Drag the structure with the mouse to rotate
5p21, resolution 1.35Å ()
Ligands: ,
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS

Template:ABSTRACT PUBMED 2196171

About this Structure

5p21 is a 1 chain structure of GTPase HRas with sequence from Homo sapiens. The April 2012 RCSB PDB Molecule of the Month feature on Ras Protein by David Goodsell is 10.2210/rcsb_pdb/mom_2012_4. Full crystallographic information is available from OCA.

See Also

Reference

  • Pai EF, Krengel U, Petsko GA, Goody RS, Kabsch W, Wittinghofer A. Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J. 1990 Aug;9(8):2351-9. PMID:2196171
  • Ho YS, Swenson L, Derewenda U, Serre L, Wei Y, Dauter Z, Hattori M, Adachi T, Aoki J, Arai H, Inoue K, Derewenda ZS. Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. Nature. 1997 Jan 2;385(6611):89-93. PMID:8985254 doi:10.1038/385089a0
  • Ma J, Karplus M. Ligand-induced conformational changes in ras p21: a normal mode and energy minimization analysis. J Mol Biol. 1997 Nov 21;274(1):114-31. PMID:9398520 doi:10.1006/jmbi.1997.1313
  • Thomas A, Bouffioux O, Geeurickx D, Brasseur R. Pex, analytical tools for PDB files. I. GF-Pex: basic file to describe a protein. Proteins. 2001 Apr 1;43(1):28-36. PMID:11170211
  • Hayward S. Peptide-plane flipping in proteins. Protein Sci. 2001 Nov;10(11):2219-27. PMID:11604529 doi:10.1110/ps.23101
  • Shortle D. Composites of local structure propensities: evidence for local encoding of long-range structure. Protein Sci. 2002 Jan;11(1):18-26. PMID:11742118
  • Ermolenko DN, Thomas ST, Aurora R, Gronenborn AM, Makhatadze GI. Hydrophobic interactions at the Ccap position of the C-capping motif of alpha-helices. J Mol Biol. 2002 Sep 6;322(1):123-35. PMID:12215419
  • Carta C, Pantaleoni F, Bocchinfuso G, Stella L, Vasta I, Sarkozy A, Digilio C, Palleschi A, Pizzuti A, Grammatico P, Zampino G, Dallapiccola B, Gelb BD, Tartaglia M. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am J Hum Genet. 2006 Jul;79(1):129-35. Epub 2006 May 1. PMID:16773572 doi:10.1086/504394

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