1afq
From Proteopedia
(New page: 200px<br /> <applet load="1afq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1afq, resolution 1.80Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AFQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFQ OCA]]. | + | 1AFQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AFQ OCA]]. |
==Reference== | ==Reference== | ||
X-ray crystal structure of gamma-chymotrypsin in hexane., Yennawar NH, Yennawar HP, Farber GK, Biochemistry. 1994 Jun 14;33(23):7326-36. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8003497 8003497] | X-ray crystal structure of gamma-chymotrypsin in hexane., Yennawar NH, Yennawar HP, Farber GK, Biochemistry. 1994 Jun 14;33(23):7326-36. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8003497 8003497] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| + | [[Category: Chymotrypsin]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Inoue, Y.]] | [[Category: Inoue, Y.]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:11:51 2007'' |
Revision as of 12:07, 30 October 2007
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CRYSTAL STRUCTURE OF BOVINE GAMMA-CHYMOTRYPSIN COMPLEXED WITH A SYNTHETIC INHIBITOR
Overview
Crystals of gamma-chymotrypsin grown in aqueous solution were soaked in, n-hexane, and the structures of both the soaked and the native crystals, were determined to 2.2-A resolution. Seven hexane molecules and 130 water, molecules were found in the hexane-soaked crystals. Two of the seven, hexane molecules are found near the active site, and the rest are close to, hydrophobic regions on or near the surface of the enzyme. In the hexane, structure, water molecules that were not observed in the native structure, form a clathrate around one of the hexane molecules. Only 97 water, molecules were found in the native structure. The temperature factors for, atoms in the hexane environment are lower than those in the aqueous, environment. There are significant changes between the two structures ... [(full description)]
About this Structure
1AFQ is a [Single protein] structure of sequence from [Bos taurus] with SO4 as [ligand]. Active as [Chymotrypsin], with EC number [3.4.21.1]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
X-ray crystal structure of gamma-chymotrypsin in hexane., Yennawar NH, Yennawar HP, Farber GK, Biochemistry. 1994 Jun 14;33(23):7326-36. PMID:8003497
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