1xkk
From Proteopedia
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[[Image:1xkk.png|left|200px]] | [[Image:1xkk.png|left|200px]] | ||
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{{STRUCTURE_1xkk| PDB=1xkk | SCENE= }} | {{STRUCTURE_1xkk| PDB=1xkk | SCENE= }} | ||
===EGFR kinase domain complexed with a quinazoline inhibitor- GW572016=== | ===EGFR kinase domain complexed with a quinazoline inhibitor- GW572016=== | ||
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{{ABSTRACT_PUBMED_15374980}} | {{ABSTRACT_PUBMED_15374980}} | ||
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==See Also== | ==See Also== | ||
| - | *[[Epidermal Growth Factor Receptor]] | + | *[[Epidermal Growth Factor Receptor|Epidermal Growth Factor Receptor]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015374980</ref><references group="xtra"/> |
[[Category: Epidermal Growth Factor Receptor]] | [[Category: Epidermal Growth Factor Receptor]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
Revision as of 10:52, 27 July 2012
Contents |
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Template:ABSTRACT PUBMED 15374980
About this Structure
1xkk is a 1 chain structure of Epidermal Growth Factor Receptor with sequence from Homo sapiens. The June 2010 RCSB PDB Molecule of the Month feature on Epidermal Growth Factor Receptor by David Goodsell is 10.2210/rcsb_pdb/mom_2010_6. Full crystallographic information is available from OCA.
See Also
Reference
- Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004 Sep 15;64(18):6652-9. PMID:15374980 doi:10.1158/0008-5472.CAN-04-1168
Categories: Epidermal Growth Factor Receptor | Homo sapiens | RCSB PDB Molecule of the Month | Transferase | Alligood, K J. | Dickerson, S H. | Ellis, B. | Gilmer, T M. | Hassell, A. | Horne, E. | Lackey, K. | McDonald, O B. | Pennisi, C. | Rusnak, D W. | Shewchuk, L M. | Truesdale, A T. | Wood, E R. | Yuan, D. | Egfr | Epidermal growth factor receptor | Kinase
