1h04
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Decay-accelerating factor (CD55), a regulator of the alternative and | + | Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55. |
==Disease== | ==Disease== | ||
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[[Category: Billington, J.]] | [[Category: Billington, J.]] | ||
[[Category: Chaudhry, Y.]] | [[Category: Chaudhry, Y.]] | ||
| - | [[Category: Evans, D | + | [[Category: Evans, D J.]] |
[[Category: Goodfellow, I.]] | [[Category: Goodfellow, I.]] | ||
| - | [[Category: Lea, S | + | [[Category: Lea, S M.]] |
[[Category: Spiller, B.]] | [[Category: Spiller, B.]] | ||
[[Category: Williams, P.]] | [[Category: Williams, P.]] | ||
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[[Category: ligand for cd97]] | [[Category: ligand for cd97]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:55:55 2008'' |
Revision as of 10:55, 21 February 2008
|
HUMAN CD55 DOMAINS 3 & 4
Contents |
Overview
Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
Disease
Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]
About this Structure
1H04 is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389
Page seeded by OCA on Thu Feb 21 12:55:55 2008
Categories: Homo sapiens | Single protein | Billington, J. | Chaudhry, Y. | Evans, D J. | Goodfellow, I. | Lea, S M. | Spiller, B. | Williams, P. | NI | Alternative splicing | Bacterial receptor | Complement decay accelerating factor | Complement pathway | Enteroviral receptor | Gpi-anchor | Ligand for cd97
