1h2q
From Proteopedia
(New page: 200px<br /> <applet load="1h2q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h2q, resolution 3.0Å" /> '''HUMAN CD55 DOMAINS 3...) |
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| - | [[Image:1h2q.gif|left|200px]]<br /> | + | [[Image:1h2q.gif|left|200px]]<br /><applet load="1h2q" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1h2q" size=" | + | |
caption="1h2q, resolution 3.0Å" /> | caption="1h2q, resolution 3.0Å" /> | ||
'''HUMAN CD55 DOMAINS 3 & 4'''<br /> | '''HUMAN CD55 DOMAINS 3 & 4'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Decay-accelerating factor (CD55), a regulator of the alternative and | + | Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1H2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1H2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H2Q OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Billington, J.]] | [[Category: Billington, J.]] | ||
[[Category: Chaudhry, Y.]] | [[Category: Chaudhry, Y.]] | ||
| - | [[Category: Evans, D | + | [[Category: Evans, D J.]] |
| - | [[Category: Goodfellow, I | + | [[Category: Goodfellow, I G.]] |
| - | [[Category: Lea, S | + | [[Category: Lea, S M.]] |
[[Category: Powell, R.]] | [[Category: Powell, R.]] | ||
| - | [[Category: Spiller, O | + | [[Category: Spiller, O B.]] |
[[Category: Williams, P.]] | [[Category: Williams, P.]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
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[[Category: ligand for cd97]] | [[Category: ligand for cd97]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:56:44 2008'' |
Revision as of 10:56, 21 February 2008
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HUMAN CD55 DOMAINS 3 & 4
Contents |
Overview
Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
Disease
Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]
About this Structure
1H2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389
Page seeded by OCA on Thu Feb 21 12:56:44 2008
Categories: Homo sapiens | Single protein | Billington, J. | Chaudhry, Y. | Evans, D J. | Goodfellow, I G. | Lea, S M. | Powell, R. | Spiller, O B. | Williams, P. | Alternative splicing | Bacterial receptor | Complement decay accelerating factor | Complement pathway | Enteroviral receptor | Gpi-anchor | Ligand for cd97
