2q15
From Proteopedia
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{{STRUCTURE_2q15| PDB=2q15 | SCENE= }} | {{STRUCTURE_2q15| PDB=2q15 | SCENE= }} | ||
===Structure of BACE complexed to compound 3a=== | ===Structure of BACE complexed to compound 3a=== | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | [[2q15]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q15 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Beta secretase|Beta secretase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017685503</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
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[[Category: Bace inhibitor complex]] | [[Category: Bace inhibitor complex]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
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Revision as of 11:29, 27 July 2012
Contents |
Structure of BACE complexed to compound 3a
Template:ABSTRACT PUBMED 17685503
About this Structure
2q15 is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. J Med Chem. 2007 Sep 6;50(18):4261-4. Epub 2007 Aug 8. PMID:17685503 doi:10.1021/jm0705408
