1o5b
From Proteopedia
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===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)=== | ===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)=== | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1o5b]] is a 2 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5B OCA]. | |
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| + | ==See Also== | ||
| + | *[[Urokinase|Urokinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015522303</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: U-plasminogen activator]] | [[Category: U-plasminogen activator]] | ||
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[[Category: Young, W B.]] | [[Category: Young, W B.]] | ||
[[Category: Ala190 upa]] | [[Category: Ala190 upa]] | ||
| + | [[Category: Blood clotting]] | ||
[[Category: Conserved water displacement hydrogen bond deficit]] | [[Category: Conserved water displacement hydrogen bond deficit]] | ||
[[Category: Factor viia]] | [[Category: Factor viia]] | ||
[[Category: Hepsin]] | [[Category: Hepsin]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: S1 site]] | [[Category: S1 site]] | ||
[[Category: Selectivity]] | [[Category: Selectivity]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Trypsin]] | [[Category: Trypsin]] | ||
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Revision as of 11:48, 27 July 2012
Contents |
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Template:ABSTRACT PUBMED 15522303
About this Structure
1o5b is a 2 chain structure of Urokinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol. 2004 Nov 19;344(2):527-47. PMID:15522303 doi:10.1016/j.jmb.2004.09.032
Categories: Homo sapiens | U-plasminogen activator | Chan, H. | Gjerstad, E. | Ho, J D. | Janc, J W. | Katz, B A. | Luong, C. | Mackman, R L. | McGrath, M E. | Mortara, K. | Somoza, J R. | Sprengeler, P A. | Tang, J. | Verner, E. | Williams, S R. | Young, W B. | Ala190 upa | Blood clotting | Conserved water displacement hydrogen bond deficit | Factor viia | Hepsin | Hydrolase | S1 site | Selectivity | Thrombin | Trypsin
