3frz

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[[Image:3frz.png|left|200px]]
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{{STRUCTURE_3frz| PDB=3frz | SCENE= }}
{{STRUCTURE_3frz| PDB=3frz | SCENE= }}
===Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554===
===Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554===
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{{ABSTRACT_PUBMED_19209845}}
{{ABSTRACT_PUBMED_19209845}}
==About this Structure==
==About this Structure==
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3FRZ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRZ OCA].
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[[3frz]] is a 1 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRZ OCA].
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==See Also==
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*[[RNA polymerase|RNA polymerase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:19209845</ref><references group="xtra"/>
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<ref group="xtra">PMID:019209845</ref><references group="xtra"/>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Parge, H E.]]
[[Category: Parge, H E.]]
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[[Category: Acetylation]]
 
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Capsid protein]]
[[Category: Capsid protein]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
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[[Category: Cytoplasm]]
 
[[Category: Endoplasmic reticulum]]
[[Category: Endoplasmic reticulum]]
[[Category: Envelope protein]]
[[Category: Envelope protein]]
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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[[Category: Ubl conjugation]]
 
[[Category: Viral nucleoprotein]]
[[Category: Viral nucleoprotein]]
[[Category: Viral polymerase]]
[[Category: Viral polymerase]]
[[Category: Virion]]
[[Category: Virion]]
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[[Category: Zinc]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:09:32 2010''
 

Revision as of 11:51, 27 July 2012

Template:STRUCTURE 3frz

Contents

Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554

Template:ABSTRACT PUBMED 19209845

About this Structure

3frz is a 1 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

Reference

  • Li H, Tatlock J, Linton A, Gonzalez J, Jewell T, Patel L, Ludlum S, Drowns M, Rahavendran SV, Skor H, Hunter R, Shi ST, Herlihy KJ, Parge H, Hickey M, Yu X, Chau F, Nonomiya J, Lewis C. Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1 ,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-on e (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor. J Med Chem. 2009 Feb 11. PMID:19209845 doi:10.1021/jm8014537

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