1ygc
From Proteopedia
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{{STRUCTURE_1ygc| PDB=1ygc | SCENE= }} | {{STRUCTURE_1ygc| PDB=1ygc | SCENE= }} | ||
===Short Factor VIIa with a small molecule inhibitor=== | ===Short Factor VIIa with a small molecule inhibitor=== | ||
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{{ABSTRACT_PUBMED_15632123}} | {{ABSTRACT_PUBMED_15632123}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1ygc]] is a 2 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YGC OCA]. | |
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| + | ==See Also== | ||
| + | *[[Factor VIIa|Factor VIIa]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:015632123</ref><references group="xtra"/> |
[[Category: Coagulation factor VIIa]] | [[Category: Coagulation factor VIIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Refino, C.]] | [[Category: Refino, C.]] | ||
[[Category: Robarge, K.]] | [[Category: Robarge, K.]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Inverted oxy-anion hole]] | [[Category: Inverted oxy-anion hole]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:48:39 2009'' | ||
Revision as of 12:14, 27 July 2012
Contents |
Short Factor VIIa with a small molecule inhibitor
Template:ABSTRACT PUBMED 15632123
About this Structure
1ygc is a 2 chain structure of Factor VIIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Olivero AG, Eigenbrot C, Goldsmith R, Robarge K, Artis DR, Flygare J, Rawson T, Sutherlin DP, Kadkhodayan S, Beresini M, Elliott LO, DeGuzman GG, Banner DW, Ultsch M, Marzec U, Hanson SR, Refino C, Bunting S, Kirchhofer D. A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo. J Biol Chem. 2005 Mar 11;280(10):9160-9. Epub 2005 Jan 4. PMID:15632123 doi:10.1074/jbc.M409068200
