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1h8b
From Proteopedia
(New page: 200px<br /> <applet load="1h8b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h8b" /> '''EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT ...) |
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| - | [[Image:1h8b.gif|left|200px]]<br /> | + | [[Image:1h8b.gif|left|200px]]<br /><applet load="1h8b" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1h8b" size=" | + | |
caption="1h8b" /> | caption="1h8b" /> | ||
'''EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN'''<br /> | '''EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The interaction between alpha-actinin and titin, two modular muscle | + | The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains. |
==About this Structure== | ==About this Structure== | ||
| - | 1H8B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http:// | + | 1H8B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Atkinson, R | + | [[Category: Atkinson, R A.]] |
| - | [[Category: Frenkiel, T | + | [[Category: Frenkiel, T A.]] |
[[Category: Joseph, C.]] | [[Category: Joseph, C.]] | ||
[[Category: Kelly, G.]] | [[Category: Kelly, G.]] | ||
| - | [[Category: Muskett, F | + | [[Category: Muskett, F W.]] |
[[Category: Nietlispach, D.]] | [[Category: Nietlispach, D.]] | ||
[[Category: Pastore, A.]] | [[Category: Pastore, A.]] | ||
[[Category: z-disk structural complex]] | [[Category: z-disk structural complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:58:31 2008'' |
Revision as of 10:58, 21 February 2008
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EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN
Overview
The interaction between alpha-actinin and titin, two modular muscle proteins, is essential for sarcomere assembly. We have solved the solution structure of a complex between the calcium-insensitive C-terminal EF-hand domain of alpha-actinin-2 and the seventh Z-repeat of titin. The structure of the complex is in a semi-open conformation and closely resembles that of myosin light chains in their complexes with heavy chain IQ motifs. However, no IQ motif is present in the Z-repeat, suggesting that the semi-open conformation is a general structural solution for calcium-independent recognition of EF-hand domains.
About this Structure
1H8B is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex., Atkinson RA, Joseph C, Kelly G, Muskett FW, Frenkiel TA, Nietlispach D, Pastore A, Nat Struct Biol. 2001 Oct;8(10):853-7. PMID:11573089
Page seeded by OCA on Thu Feb 21 12:58:31 2008
