1a3c
From Proteopedia
(New page: 200px<br /> <applet load="1a3c" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a3c, resolution 1.6Å" /> '''PYRR, THE BACILLUS S...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1A3C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]] with SM and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A3C OCA]]. | + | 1A3C is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]] with SM and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: PRA, SM1 and SM2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A3C OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:13:39 2007'' |
Revision as of 12:08, 30 October 2007
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PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM
Overview
BACKGROUND: The expression of pyrimidine nucleotide biosynthetic (pyr), genes in Bacillus subtilis is regulated by transcriptional attenuation., The PyrR attenuation protein binds to specific sites in pyr mRNA, allowing, the formation of downstream terminator structures. UMP and, 5-phosphoribosyl-1-pyrophosphate (PRPP), a nucleotide metabolite, are, co-regulators with PyrR. The smallest RNA shown to bind tightly to PyrR is, a 28-30 nucleotide stem-loop that contains a purine-rich bulge and a, putative-GNRA tetraloop. PyrR is also a uracil phosphoribosyltransferase, (UPRTase), although the relationship between enzymatic activity and RNA, recognition is unclear, and the UPRTase activity of PyrR is not, physiologically significant in B. subtilis. Elucidating the role of PyrR, structural ... [(full description)]
About this Structure
1A3C is a [Single protein] structure of sequence from [Bacillus subtilis] with SM and SO4 as [ligands]. Structure known Active Sites: PRA, SM1 and SM2. Full crystallographic information is available from [OCA].
Reference
Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase., Tomchick DR, Turner RJ, Switzer RL, Smith JL, Structure. 1998 Mar 15;6(3):337-50. PMID:9551555
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