1hjo
From Proteopedia
(New page: 200px<br /> <applet load="1hjo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hjo, resolution 2.30Å" /> '''HEAT-SHOCK 70KD PRO...) |
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| - | [[Image:1hjo.gif|left|200px]]<br /> | + | [[Image:1hjo.gif|left|200px]]<br /><applet load="1hjo" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1hjo" size=" | + | |
caption="1hjo, resolution 2.30Å" /> | caption="1hjo, resolution 2.30Å" /> | ||
'''HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN'''<br /> | '''HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Hsp70 proteins are highly conserved proteins induced by heat shock and | + | Hsp70 proteins are highly conserved proteins induced by heat shock and other stress conditions. An ATP-binding domain of human Hsp70 protein has been crystallized in two major morphological forms at pH 7.0 in the presence of PEG 8000 and CaCl2. Both crystal forms belong to the orthorhombic space group P212121, but show no resemblance in unit-cell parameters. Analysis of the crystal structures for both forms shows a 1-2 A shift of one of the subdomains of the protein. This conformational change could reflect a 'natural' flexibility of the protein which might be relevant to ATP binding and may facilitate the interaction of other proteins with Hsp70 protein. |
==About this Structure== | ==About this Structure== | ||
| - | 1HJO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, CL and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] Full crystallographic information is available from [http:// | + | 1HJO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Freeman, B | + | [[Category: Freeman, B C.]] |
[[Category: Joachimiak, A.]] | [[Category: Joachimiak, A.]] | ||
| - | [[Category: Morimoto, R | + | [[Category: Morimoto, R I.]] |
[[Category: Osipiuk, J.]] | [[Category: Osipiuk, J.]] | ||
| - | [[Category: Walsh, M | + | [[Category: Walsh, M A.]] |
[[Category: ADP]] | [[Category: ADP]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: heat shock]] | [[Category: heat shock]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:02:01 2008'' |
Revision as of 11:02, 21 February 2008
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HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN
Overview
Hsp70 proteins are highly conserved proteins induced by heat shock and other stress conditions. An ATP-binding domain of human Hsp70 protein has been crystallized in two major morphological forms at pH 7.0 in the presence of PEG 8000 and CaCl2. Both crystal forms belong to the orthorhombic space group P212121, but show no resemblance in unit-cell parameters. Analysis of the crystal structures for both forms shows a 1-2 A shift of one of the subdomains of the protein. This conformational change could reflect a 'natural' flexibility of the protein which might be relevant to ATP binding and may facilitate the interaction of other proteins with Hsp70 protein.
About this Structure
1HJO is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Adenosinetriphosphatase, with EC number 3.6.1.3 Full crystallographic information is available from OCA.
Reference
Structure of a new crystal form of human Hsp70 ATPase domain., Osipiuk J, Walsh MA, Freeman BC, Morimoto RI, Joachimiak A, Acta Crystallogr D Biol Crystallogr. 1999 May;55(Pt 5):1105-7. PMID:10216320
Page seeded by OCA on Thu Feb 21 13:02:01 2008
Categories: Adenosinetriphosphatase | Homo sapiens | Single protein | Freeman, B C. | Joachimiak, A. | Morimoto, R I. | Osipiuk, J. | Walsh, M A. | ADP | CA | CL | Atp-binding | Chaperone | Heat shock
