1v3x

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[[Image:1v3x.png|left|200px]]
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{{STRUCTURE_1v3x| PDB=1v3x | SCENE= }}
{{STRUCTURE_1v3x| PDB=1v3x | SCENE= }}
===Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine===
===Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine===
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{{ABSTRACT_PUBMED_15456260}}
{{ABSTRACT_PUBMED_15456260}}
==About this Structure==
==About this Structure==
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[[1v3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3X OCA].
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[[1v3x]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V3X OCA].
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==See Also==
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*[[Factor Xa|Factor Xa]]
==Reference==
==Reference==
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<ref group="xtra">PMID:15456260</ref><ref group="xtra">PMID:9618463</ref><ref group="xtra">PMID:8939944</ref><ref group="xtra">PMID:8355279</ref><references group="xtra"/>
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<ref group="xtra">PMID:015456260</ref><ref group="xtra">PMID:009618463</ref><ref group="xtra">PMID:008939944</ref><ref group="xtra">PMID:008355279</ref><references group="xtra"/>
[[Category: Coagulation factor Xa]]
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 15:06, 27 July 2012

Image:1v3x.png

Template:STRUCTURE 1v3x

Contents

Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine

Template:ABSTRACT PUBMED 15456260

About this Structure

1v3x is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Haginoya N, Kobayashi S, Komoriya S, Yoshino T, Suzuki M, Shimada T, Watanabe K, Hirokawa Y, Furugori T, Nagahara T. Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element. J Med Chem. 2004 Oct 7;47(21):5167-82. PMID:15456260 doi:10.1021/jm049884d
  • Kamata K, Kawamoto H, Honma T, Iwama T, Kim SH. Structural basis for chemical inhibition of human blood coagulation factor Xa. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6630-5. PMID:9618463
  • Brandstetter H, Kuhne A, Bode W, Huber R, von der Saal W, Wirthensohn K, Engh RA. X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition. J Biol Chem. 1996 Nov 22;271(47):29988-92. PMID:8939944
  • Padmanabhan K, Padmanabhan KP, Tulinsky A, Park CH, Bode W, Huber R, Blankenship DT, Cardin AD, Kisiel W. Structure of human des(1-45) factor Xa at 2.2 A resolution. J Mol Biol. 1993 Aug 5;232(3):947-66. PMID:8355279 doi:http://dx.doi.org/10.1006/jmbi.1993.1441

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