1hky
From Proteopedia
(New page: 200px<br /><applet load="1hky" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hky" /> '''SOLUTION STRUCTURE OF A PAN MODULE FROM EIME...) |
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'''SOLUTION STRUCTURE OF A PAN MODULE FROM EIMERIA TENELLA'''<br /> | '''SOLUTION STRUCTURE OF A PAN MODULE FROM EIMERIA TENELLA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Micronemes, specialised organelles found in all apicomplexan parasites, secrete molecules that are essential for parasite attachment and invasion | + | Micronemes, specialised organelles found in all apicomplexan parasites, secrete molecules that are essential for parasite attachment and invasion of host cells. EtMIC5 is one such microneme protein that contains eleven tandemly repeating modules. These modules have homology with the PAN module superfamily. Members of this family are found in blood clotting proteins, some growth factors and some nematode proteins. This paper presents the structure of the 9th PAN module in EtMIC5, determined using high resolution NMR. The structure shows similarities to and some differences from the N-terminal module of hepatocyte growth factor (HGF), the only previous member of the PAN family with known structure. |
==About this Structure== | ==About this Structure== | ||
| - | 1HKY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Eimeria_tenella Eimeria tenella]. Full crystallographic information is available from [http:// | + | 1HKY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Eimeria_tenella Eimeria tenella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Eimeria tenella]] | [[Category: Eimeria tenella]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Brown, P | + | [[Category: Brown, P J.]] |
| - | [[Category: Campbell, I | + | [[Category: Campbell, I D.]] |
[[Category: Mulvey, D.]] | [[Category: Mulvey, D.]] | ||
| - | [[Category: Potts, J | + | [[Category: Potts, J R.]] |
| - | [[Category: Tomley, F | + | [[Category: Tomley, F M.]] |
[[Category: eimeria tenella]] | [[Category: eimeria tenella]] | ||
[[Category: nmr]] | [[Category: nmr]] | ||
[[Category: pan module]] | [[Category: pan module]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:02:23 2008'' |
Revision as of 11:02, 21 February 2008
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SOLUTION STRUCTURE OF A PAN MODULE FROM EIMERIA TENELLA
Overview
Micronemes, specialised organelles found in all apicomplexan parasites, secrete molecules that are essential for parasite attachment and invasion of host cells. EtMIC5 is one such microneme protein that contains eleven tandemly repeating modules. These modules have homology with the PAN module superfamily. Members of this family are found in blood clotting proteins, some growth factors and some nematode proteins. This paper presents the structure of the 9th PAN module in EtMIC5, determined using high resolution NMR. The structure shows similarities to and some differences from the N-terminal module of hepatocyte growth factor (HGF), the only previous member of the PAN family with known structure.
About this Structure
1HKY is a Single protein structure of sequence from Eimeria tenella. Full crystallographic information is available from OCA.
Reference
Solution structure of a PAN module from the apicomplexan parasite Eimeria tenella., Brown PJ, Mulvey D, Potts JR, Tomley FM, Campbell ID, J Struct Funct Genomics. 2003;4(4):227-34. PMID:15185963
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