1hp3
From Proteopedia
(New page: 200px<br /><applet load="1hp3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hp3" /> '''C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-H...) |
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| - | [[Image:1hp3.jpg|left|200px]]<br /><applet load="1hp3" size=" | + | [[Image:1hp3.jpg|left|200px]]<br /><applet load="1hp3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1hp3" /> | caption="1hp3" /> | ||
'''C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-HV2A (CT-HV2A)'''<br /> | '''C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-HV2A (CT-HV2A)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have isolated a novel family of insect-selective neurotoxins that | + | We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with omega-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities. |
==About this Structure== | ==About this Structure== | ||
| - | 1HP3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1HP3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP3 OCA]. |
==Reference== | ==Reference== | ||
Discovery and structure of a potent and highly specific blocker of insect calcium channels., Wang XH, Connor M, Wilson D, Wilson HI, Nicholson GM, Smith R, Shaw D, Mackay JP, Alewood PF, Christie MJ, King GF, J Biol Chem. 2001 Oct 26;276(43):40306-12. Epub 2001 Aug 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11522785 11522785] | Discovery and structure of a potent and highly specific blocker of insect calcium channels., Wang XH, Connor M, Wilson D, Wilson HI, Nicholson GM, Smith R, Shaw D, Mackay JP, Alewood PF, Christie MJ, King GF, J Biol Chem. 2001 Oct 26;276(43):40306-12. Epub 2001 Aug 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11522785 11522785] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: King, G | + | [[Category: King, G F.]] |
| - | [[Category: Wang, X | + | [[Category: Wang, X H.]] |
[[Category: cystine knot]] | [[Category: cystine knot]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:03:25 2008'' |
Revision as of 11:03, 21 February 2008
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C-TERMINAL TRUNCATION OF OMEGA-ATRACOTOXIN-HV2A (CT-HV2A)
Overview
We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with omega-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.
About this Structure
1HP3 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Discovery and structure of a potent and highly specific blocker of insect calcium channels., Wang XH, Connor M, Wilson D, Wilson HI, Nicholson GM, Smith R, Shaw D, Mackay JP, Alewood PF, Christie MJ, King GF, J Biol Chem. 2001 Oct 26;276(43):40306-12. Epub 2001 Aug 24. PMID:11522785
Page seeded by OCA on Thu Feb 21 13:03:25 2008
