2v70

From Proteopedia

Revision as of 12:11, 30 October 2007

THIRD LRR DOMAIN OF HUMAN SLIT2

Overview

Slit2 and Roundabout 1 (Robo1) provide a key ligand-receptor interaction, for the navigation of commissural neurons during the development of the, central nervous system. Slit2 is a large multidomain protein containing an, unusual domain organization of four tandem leucine-rich repeat (LRR), domains at its N-terminus. These domains are well known to mediate, protein-protein interactions; indeed, the Robo1-binding region has been, mapped to the concave face of the second LRR domain. It has also been, shown that the fourth LRR domain may mediate Slit dimerization and that, both the first and second domains can bind heparin. Thus, while roles have, been ascribed for three of the LRR domains, there is still no known role, for the third domain. Each of the four LRR domains from human Slit2 ... [(full description)]

About this Structure

2V70 is a [Single protein] structure of sequence from [Homo sapiens] with NAG as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3., Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA, Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):961-8. Epub 2007, Aug 17. PMID:17704564

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